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• 2024-09-14 07:00 HIF-2α- dependent induction of miR-29a restrains T - Nature.com
• 2024-08-28 07:00 Pharmacologic HIF stabilization activates costimulatory receptor expression to increase antitumor efficacy of adoptive T cell therapy - Science
• 2024-09-20 07:00 MOL Invests in HIF Global, a U.S.-based company of e-Fuels -Toward the Decarbonization of the Mobility Industry with synthetic fuels - - 株式会社商船三井
• 2024-05-16 07:00 HIF Global selects Johnson Matthey’s methanol technology for the largest e methanol plant in South America - Johnson Matthey
• 2024-09-24 07:00 A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein - ScienceDirect.com
• 2024-08-06 07:00 Hif-2α programs oxygen chemosensitivity in chromaffin cells - JCI
• 2024-08-22 07:00 From Bench to Bedside: HIF-2α Inhibition in RCC - OncLive
• 2024-07-03 23:12 Immunometabolism and Sepsis: A Role for HIF? - Frontiers
• 2024-07-24 07:00 HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma - Nature.com
• 2024-09-11 07:00 HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis - Science
• 2024-08-06 07:00 A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH - ScienceDirect.com
• 2024-09-03 07:00 Citrullination modulation stabilizes HIF-1α to promote tumour progression - Nature.com
• 2024-06-27 07:00 Targeting HIF-1 to treat AML - Nature.com
• 2024-04-18 07:00 The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia - Nature.com
• 2024-11-25 08:00 FBP1 over-expression suppresses HIF-1α in papillary thyroid cancer - Nature.com
• 2024-09-19 07:00 The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma - Nature.com
• 2024-05-15 07:00 Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway - Nature.com
• 2024-10-04 07:00 MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice - Nature.com
• 2024-11-14 08:00 Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation - Nature.com
• 2024-06-11 07:00 DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer - Nature.com
• 2024-06-26 07:00 A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity - Wiley Online Library
• 2024-11-11 08:00 Abstract 4138199: Examining the regulating mechanism of the HIF-FOXM1 axis in promoting adult pig cardiomyocyte proliferation - AHA Journals
• 2024-11-15 08:00 HIF-1α knockdown attenuates phenotypic transformation and oxidative stress induced by high salt in human aortic vascular smooth muscle cells - Nature.com
• 2024-02-27 08:00 The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation - ScienceDirect.com
• 2024-08-23 07:00 LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia - Nature.com
• 2024-10-17 07:00 Genistein inhibits HIF-1α and attenuates high glucose-induced peritoneal mesothelial-mesenchymal transition and fibrosis via the mTOR/OGT pathway - Nature.com
• 2024-05-16 02:04 HIF-1α Mediates Immunosuppression and Chemoresistance in Colorectal Cancer by Inhibiting CXCL9, −10 and −11 - ScienceDirect.com
• 2024-10-09 07:00 Abstract Tu120: Sarm1 promotes diabetic cardiomyopathy by regulating HIF signaling, lipotoxicity and mitochondrial dysfunction - AHA Journals
• 2024-06-05 07:00 HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model - Nature.com
• 2024-06-04 07:00 Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α - Nature.com
• 2024-11-16 08:00 Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway - Nature.com
• 2024-11-23 08:00 Association of serum HIF-1α levels with coronary artery calcification in patients of non-dialysis chronic kidney disease - Nature.com
• 2024-11-14 08:00 Ulinastatin attenuates renal fibrosis by regulating AMPK/HIF-1α signaling pathway-mediated glycolysis - Nature.com
• 2024-10-09 07:00 Abstract Tu136: HIF-1α a novel therapeutic target to reduce Cardiac Ischemia Reperfusion Injury during AMI - AHA Journals
• 2024-12-04 08:00 Is there a future for e-fuels? - Mobility Plaza
• 2024-05-02 07:00 NREP, transcriptionally upregulated by HIF-1α, aggravates breast cancer cell growth and metastasis by promoting glycolysis - Nature.com
• 2024-03-12 07:00 The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair | Bone Research - Nature.com
• 2024-03-19 07:00 MOL, Idemitsu, HIF Team up to Develop e-fuel/e-methanol Supply Chain, Including Marine Transport of CO - 株式会社商船三井
• 2024-02-13 08:00 Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin - Nature.com
• 2024-04-04 07:00 Hypoxic preconditioning accelerates the healing of ischemic intestinal injury by activating HIF-1α/PPARα pathway-mediated fatty acid oxidation - Nature.com
• 2024-05-31 20:06 Stilbenoid derivatives as potent inhibitors of HIF-1α-centric cancer metabolism under hypoxia - ScienceDirect.com
• 2024-05-06 07:00 HIF-1α participates in the regulation of S100A16-HRD1-GSK3β/CK1α pathway in renal hypoxia injury - Nature.com
• 2024-04-22 07:00 MED15 is upregulated by HIF-2α and promotes proliferation and metastasis in clear cell renal cell carcinoma via activation of SREBP-dependent fatty acid synthesis - Nature.com
• 2024-07-10 07:00 HIF‐1α Affects Sperm Autophagy and Motility - Mo - 2024 - Andrologia - Wiley Online Library
• 2024-07-01 07:00 Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ - Nature.com
• 2024-04-02 07:00 Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis - Nature.com
• 2024-05-01 07:00 Glutamine-derived aspartate is required for eIF5A hypusination-mediated translation of HIF-1α to induce the polarization of tumor-associated macrophages - Nature.com
• 2024-04-23 07:00 Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes - ScienceDirect.com
• 2024-09-19 07:00 Latham & Watkins Advises HIF Global on Investment by MOL - Latham & Watkins LLP
• 2024-02-10 15:52 HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity - ScienceDirect.com
• 2024-02-16 08:00 HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process - Nature.com
• 2024-08-13 07:00 Latham Watkins Advises HIF Global on US36 Million Equity Investment Japan Organization Metals Energy - Latham & Watkins LLP
• 2024-02-15 08:00 PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer - Frontiers
• 2024-01-20 08:00 Linking HIF oxygen-sensing system diversity to hypoxia fitness in Eleutheronema: Molecular characterization and transcriptional response to hypoxia exposure - ScienceDirect.com
• 2024-01-10 08:00 Salvianolic acid A attenuates arsenic-induced ferroptosis and kidney injury via HIF-2α/DUOX1/GPX4 and iron homeostasis - ScienceDirect.com
• 2024-05-23 07:00 Transmissible gastroenteritis virus induces inflammatory responses via RIG-I/NF-κB/HIF-1α/glycolysis axis in intestinal organoids and in vivo - American Society for Microbiology
• 2024-01-09 08:00 Hsa_circ_0081065 exacerbates IH-induced EndMT via regulating miR-665/HIF-1α signal axis and HIF-1α nuclear translocation - Nature.com
• 2023-10-27 07:00 MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy | Circulation - AHA Journals
• 2017-11-29 05:52 HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia - ScienceDirect.com
• 2023-08-09 07:00 Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells - Nature.com
• 2022-12-06 08:00 HIF Global engages Bechtel, Siemens Energy, and Topsoe for eFuels project in the USA - Bechtel
• 2022-06-20 07:00 The effect of HIF on metabolism and immunity - Nature.com
• 2017-12-12 04:19 HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption - ScienceDirect.com
• 2022-03-05 03:12 Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity - pnas.org
• 2022-03-03 00:30 RETRACTED: Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization - pnas.org
• 2024-07-09 07:00 New space for innovation: the renovated and extended HIF building of the D-BAUG – Staffnet - ETH Zürich
• 2024-02-27 08:00 JFE Steel Corporation - jfe-steel.co.jp
• 2022-10-08 07:00 HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis | Cell Death & Disease - Nature.com
• 2021-09-17 22:25 Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch - Science
• 2021-09-16 05:52 Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling - Science
• 2022-03-04 20:34 Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities - pnas.org
• 2021-12-08 04:04 Hydrologic Instrumentation Facility (HIF) - United States Geological Survey
• 2023-06-10 07:00 Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function - Journal of Translational Medicine
• 2022-03-03 17:38 Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways - pnas.org
• 2022-05-09 07:00 Identification of oleoylethanolamide as an endogenous ligand for HIF-3α - Nature.com
• 2021-07-14 07:00 The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling - Nature.com
• 2023-05-24 07:00 Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy - Nature.com
• 2014-10-09 07:00 Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation - ScienceDirect.com
• 2023-11-23 08:00 Long-term HIF-1α stabilization reduces respiration, promotes mitophagy, and results in retinal cell death - Nature.com
• 2021-04-20 07:00 Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells - ScienceDirect.com
• 2022-02-01 08:00 Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers - ScienceDirect.com
• 2023-01-19 08:00 BAP1 is a novel regulator of HIF-1α - pnas.org
• 2022-11-30 08:00 Chronic hypoxia leads to cognitive impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation - Nature.com
• 2023-07-27 07:00 A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress - Nature.com
• 2014-09-26 07:00 mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity - Science
• 2019-02-26 08:00 Trophoblast-Specific Expression of Hif-1α Results in Preeclampsia-Like Symptoms and Fetal Growth Restriction - Nature.com
• 2018-11-12 08:00 Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage - Nature.com
• 2020-08-17 07:00 HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice - Nature.com
• 2021-06-07 07:00 A small molecule HIF-1α stabilizer that accelerates diabetic wound healing - Nature.com
• 2019-04-01 07:00 Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells - Nature.com
• 2023-10-02 07:00 UBE3B promotes breast cancer progression by antagonizing HIF-2α degradation - Nature.com
• 2017-11-02 07:00 HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy - Nature.com
• 2016-09-05 07:00 On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models - Nature.com
• 2016-12-09 08:00 K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression - Nature.com
• 2018-11-26 08:00 HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts - Nature.com
• 2023-10-20 07:00 YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions - Nature.com
• 2023-01-31 08:00 HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease - ScienceDirect.com
• 2016-11-04 07:00 Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition - Nature.com
• 2019-02-25 08:00 Bidirectional modulation of HIF-2 activity through chemical ligands - Nature.com
• 2018-09-12 07:00 Stabilization of HIF-2α impacts pancreas growth - Nature.com

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